2-(4-FORMYLPHENOXY)ACETAMIDE synthesis
- Product Name:2-(4-FORMYLPHENOXY)ACETAMIDE
- CAS Number:135857-20-4
- Molecular formula:C9H9NO3
- Molecular Weight:179.17
683-57-8
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$6.00/1g
123-08-0
961 suppliers
$5.00/10g
135857-20-4
30 suppliers
$60.00/100mg
Yield:-
Reaction Conditions:
with potassium carbonate in acetonitrile at 50; for 5 h;
Steps:
3 preparation of 2-(4-formylphenoxy)acetamide
P-Hydroxybenzaldehyde (24.4 g, 0.2 mol) was added to a 500 ml three-necked flask,2-bromoacetamide (27.68, 0.2 mol) and potassium carbonate (55.2 g, 0.4 mol) followed by 300 ml of acetonitrile and stirring at 50 ° C for 5 h.After cooling to room temperature, insoluble matter was filtered off, and the potassium salt of the filtrate was evaporated to dryness. The residue was dissolved in 200 ml of methylene chloride, washed with water 3 times,Dried over anhydrous magnesium sulfate, filtered and the filtrate was evaporated. The crude product was dried to give 27.31 g of product in 76.3% yield.
References:
Beijing Second Pharmaceutical Co.,Ltd. (BSPC);SONG, BO;GAO, BO;LI, RIDONG;YANG, YAN CN103739540, 2016, B Location in patent:Paragraph 0089-0093
123-08-0
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79-07-2
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135857-20-4
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$60.00/100mg
144-48-9
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123-08-0
961 suppliers
$5.00/10g
135857-20-4
30 suppliers
$60.00/100mg