2-(4-ISOBUTYLPHENYL)PROPANOHYDRAZIDE synthesis
- Product Name:2-(4-ISOBUTYLPHENYL)PROPANOHYDRAZIDE
- CAS Number:127222-69-9
- Molecular formula:C13H20N2O
- Molecular Weight:220.31
41283-72-1
67 suppliers
$39.00/250mg
127222-69-9
28 suppliers
inquiry
Yield:127222-69-9 96%
Reaction Conditions:
with hydrazine hydrate in ethanol; for 10 h;Reflux;
Steps:
2-[4-(2-methylpropyl)phenyl]propanehydrazide (3)
The mixture of ethyl ester of Ibuprofen 2 (2 g, 8.5 mmol) and hydrazine hydrate (0.8 mL, 16 mmol) in absolute ethanol (30 mL) was refluxed for 10 h. The solvent was removed under reduced pressure and the residue was added to ice cold water. The solid separated was filtered, washed and dried. The solid was purified by recrystallization from ethanol to get pure product 3 (1.7 g, 96%) as a white solid.
References:
Rakesh, Kodagahalli S.;Jagadish, Swamy;Vinayaka, Ajjampura C.;Hemshekhar, Mahadevappa;Paul, Manoj;Thushara, Ram M.;Sundaram, Mahalingam S.;Swaroop, Toreshettahally R.;Mohan, Chakrabhavi D.;Basappa;Sadashiva, Marilinganadoddi P.;Kemparaju, Kempaiah;Girish, Kesturu S.;Rangappa, Kanchugarakoppal S. [PLoS ONE,2014,vol. 9,# 9,art. no. E107182,p. e2718 - e2718]
61566-34-5
79 suppliers
$6.00/250mg
127222-69-9
28 suppliers
inquiry
15687-27-1
847 suppliers
$5.00/1g
127222-69-9
28 suppliers
inquiry
![1-Propanone, 1-(1H-benzotriazol-1-yl)-2-[4-(2-methylpropyl)phenyl]-](/CAS/20200515/GIF/230644-97-0.gif)
230644-97-0
1 suppliers
inquiry
127222-69-9
28 suppliers
inquiry
![2,5-Pyrrolidinedione, 1-[2-[4-(2-methylpropyl)phenyl]-1-oxopropoxy]-](/CAS/20180529/GIF/104400-52-4.gif)
104400-52-4
0 suppliers
inquiry
127222-69-9
28 suppliers
inquiry