2-(4-METHYLPHENYL)PIPERIDINE synthesis

Yield:94 % ee

Reaction Conditions:

with glucose dehydrogenase;D-glucose;pyridoxal 5'-phosphate;ω-transaminase ATA-113;Mycobacterium marinum carboxylic acid reductase;Streptomyces sp. GF₃₅₄₆ (S)-imine reductase;NAD;rac-Ala-OH;lactate dehydrogenase in aq. phosphate buffer at 30; for 24 h;Enzymatic reaction;stereoselective reaction;

References:

France, Scott P.;Hussain, Shahed;Hill, Andrew M.;Hepworth, Lorna J.;Howard, Roger M.;Mulholland, Keith R.;Flitsch, Sabine L.;Turner, Nicholas J. [ACS Catalysis,2016,vol. 6,# 6,p. 3753 - 3759]