2,5-dichloro-4-ethoxypyriMidine synthesis

Yield:1351762-11-2 81%

Reaction Conditions:

in ethanol at 20; for 2 h;

Steps:

96.1

Step 1: 2,5-dichloro-4-ethoxypyrimidine (1452) (1453) [00474] A solution of 2,4,5-trichloropyrimidine (1.00 g, 5.43 mmol) and CH₃CH₂ONa (0.73 g, 10.87 mmol) in EtOH (10 mL) was stirred at RT for 2 hours. The mixture was diluted with water (20 mL) and extracted with EtOAc (30 mL*2). The combined organic phase was washed with brine (30 mL), dried over Na₂S0₄, filtered and concentrated in vacuo. The residue was purified by flash (1454) chromatography on silica gel (PE/EtOAc = 10/1) to afford 2,5-dichloro-4-ethoxypyrimidine (0.95 g, 81%) as a white solid. [M+H] Calc’d for C₆H₆Cl₂N₂0, 192.9; Found, 192.9.

References:

WO2020/6497,2020,A1 Location in patent:Paragraph 00474