2,5-Dichloro-N-methoxy-N-methylisonicotinamide synthesis
- Product Name:2,5-Dichloro-N-methoxy-N-methylisonicotinamide
- CAS Number:864674-17-9
- Molecular formula:C8H8Cl2N2O2
- Molecular Weight:235.07
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Yield:864674-17-9 81%
Steps:
42
Example 42; Synthesis of 25-dichloro-4-acetYlpyridine ; [0141] Commercially available 2,5-dichloroisonicotinic acid was converted to the Weinreb amide in 81 % yield. The Weinreb amide was converted to the desired 2,5- dichloro-4-acetylpyridine by reaction with methylmagnesium iodide in 23 % yield. Unreacted Weinreb amide (28%) was also recovered.
References:
WO2005/84439,2005,A1 Location in patent:Page/Page column 45
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