2,5-difluoroterephthalic acid synthesis
- Product Name:2,5-difluoroterephthalic acid
- CAS Number:655-14-1
- Molecular formula:C8H4F2O4
- Molecular Weight:202.11
103877-80-1
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Yield:-
Reaction Conditions:
with potassium permanganate in water at 100;
Steps:
198 Synthesis of Compound 1 :
Into a 50-mL of round-bottom flask, was placed a solution of 2,5-difluoro-4-methylbenzoic acid (1 g, 5.810 mmol, 1 equiv) and KMn04 (4.59 g, 29.048 mmol, 5 equiv) in water (20 mL). The resulting solution was stirred overnight at 100°C. The solids were filtered out. The pH of the filtrate was adjusted to 3 with HCI (6 mol/L). The solids were collected by filtration, washed by cool water and dried in vacuo. This resulted in 2,5- difluorobenzene-1 ,4-dicarboxylic acid.
References:
THE SCRIPPS RESEARCH INSTITUTE;EXPANSION THERAPEUTICS, INC.;DISNEY, Matthew;BLIZZARD, Timothy, Allen;RZUCZEK, Suzanne;NDUNGU, John;VACCA, Joseph;JENNINGS, Andy;PUSHECHNIKOV, Alexei WO2019/99777, 2019, A2 Location in patent:Paragraph 001088-001090
35335-08-1
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![Ethanamine, N-[(3,5-dichlorophenyl)methylene]-2,2-diethoxy-](/CAS/20210305/GIF/1000210-73-0.gif)
1000210-73-0
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655-14-1
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