ChemicalBook CAS DataBase List 2-(5-METHYL-2-PHENYL-1,3-OXAZOL-4-YL)ACETIC ACID

2-(5-METHYL-2-PHENYL-1,3-OXAZOL-4-YL)ACETIC ACID synthesis

10synthesis methods

Product Name:2-(5-METHYL-2-PHENYL-1,3-OXAZOL-4-YL)ACETIC ACID
CAS Number:107367-98-6
Molecular formula:C12H11NO3
Molecular Weight:217.22

Ethanamine, N-[(3,5-dichlorophenyl)methylene]-2,2-diethoxy-

1000210-73-0
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2-(5-METHYL-2-PHENYL-1,3-OXAZOL-4-YL)ACETIC ACID

107367-98-6
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$38.00/250mg

Yield: 44%

Reaction Conditions:

with potassium hydroxide in ethanol;water

Steps:

31.c (c)
(c) 2-(5-methyl-2-phenyloxazol-4-yl)acetic acid (84) KOH (1.79 g, 31.8 mmole) was added to a solution of 4-(2-Cyanoethyl)-5-methyl-2-phenyloxazole (83) (1.5 g, 7.07 mmole) in ethanol/H₂O at room temperature. The mixture was then heated at reflux for 20 hours. The solvent was removed at reduced pressure. The residue was dissolved in H₂O, washed with ether, and the aqueous layer was acidified with 1 N HCl. The product was collected by filtration and dried to give a white powder. 0.7 g (44% yield).

References:

Bigge, Christopher Franklin;Bridges, Alexander James;Casimiro-Garcia, Agustin;Fakhoury, Stephen Alan;Lee, Helen Tsenwhei;Reed, Jessica;Schaum, Robert;Schlosser, Kevin Matthew;Sexton, Karen;Zhou, Hairong US2003/171377, 2003, A1

1000210-73-0
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107367-98-6
58 suppliers
$38.00/250mg

References

524959-64-6 Synthesis