2,6-Diaminobenzoic acid methyl ester synthesis

Yield:32114-64-0 96%

Reaction Conditions:

palladium on charcoal in methanol;

Steps:

13.b b.

b. Methyl 2,6-diaminobenzoate Methyl 2,6-dinitrobenzoate (15.0 gm.) is suspended in methanol (500 ml.) and 5% palladium on charcoal (1.5 gm.) added. Reduction is carried out on a Parr apparatus for 2 hours. The solution is filtered with suction and the catalyst washed with a few ml. of methanol. Removal of the methanol gives a brown crystalline product. Extraction with chloroform (50 ml.) and treatment with Darco gives the product (10.9 gm. 96% yield, m.p. 78°-79.5°).

References:

US3993679,1976,A