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ChemicalBook CAS DataBase List 2,6-DIBROMOBENZALDEHYDE
67713-23-9

2,6-DIBROMOBENZALDEHYDE synthesis

7synthesis methods
1,3-Dibromobenzene

108-36-1

N,N-Dimethylformamide

68-12-2

2,6-DIBROMOBENZALDEHYDE

67713-23-9

To a tetrahydrofuran (THF, 180 mL) solution of diisopropylamine (iPr2NH, 21.2 mL, 150 mmol) was slowly added n-butyllithium (n-BuLi, 1.6 M, 94 mL, 150 mmol) at 0 °C. The reaction mixture was stirred at 0 °C for 30 min and then cooled to -78 °C. Subsequently, a solution of 1,3-dibromobenzene (17.6 g, 74.6 mmol) in THF (80 mL) was slowly added over 20 min. The mixture was continued to be stirred at -78 °C for 30 min and then N,N-dimethylformamide (DMF, 11.6 mL, 150 mmol) was added. The reaction mixture was stirred at -78 °C for 1 h. The reaction was quenched with 2.5 M sulfuric acid (H2SO4, 350 mL) and extracted with a solvent mixture of ethyl acetate/ether (50/50, 3 x 300 mL). The organic phases were combined, dried with anhydrous magnesium sulfate (MgSO4), filtered and the filtrate was concentrated to give 2,6-dibromobenzaldehyde (17.6 g, 89% yield). The product was characterized by 1H NMR (250 MHz, CDCl3): δ 10.3 (s, 1H), 7.65 (d, J = 8.0 Hz, 2H), 7.23 (t, J = 8.1 Hz, 1H).

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Yield:-

Steps:

Multi-step reaction with 3 steps
1: N-Bromosuccinimide / chloroform / 2.5 h / 40 - 50 °C
2: n-butyllithium; N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 1.17 h / -60 - 0 °C
3: phosphoric acid; hydroxyapatite / 1 h / 150 °C / Inert atmosphere

References:

Henan Normal University;Chen Qi;Wang Jiahao;Zhou Yingjie CN109400453, 2019, A

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