2,6-Dichloro-5-fluoronicotinamide synthesis
- Product Name:2,6-Dichloro-5-fluoronicotinamide
- CAS Number:113237-20-0
- Molecular formula:C6H3Cl2FN2O
- Molecular Weight:209.01
82671-02-1
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113237-20-0
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$5.00/250mg
Yield:113237-20-0 99.5%
Reaction Conditions:
with sulfuric acid at 62; for 1 h;
Steps:
1 Step 1) 2,6-Dichloro-5-fluoronicotinamide
Weigh 2,6-dichloro-5-fluoro-pyridine-3-carbonitrile (24.8 g, 130 mmol)Concentrated sulfuric acid (125 mL) was added to a 500 ml flask, and the mixture was heated to 62 ° C for 1 hour.After cooling to room temperature, the reaction solution was poured into ice water (800 mL) and ethyl acetate (300 mL×4).The organic phase was washed successively with water (100 mL), saturated sodium bicarbonate (100 mL) and brine (50 mL).Dry over anhydrous sodium sulfate.Filtered, the filtrate was dried,A pale yellow solid (27.0 g, 99.5%).
References:
Guangdong Dongyangguang Pharmaceutical Co., Ltd.;Wang Xiaojun;Zuo Yinglin;Yu Chuan;Yang Chuanwen;Wang Jiancheng;Li Jing;Cao Shengtian;Wu Fangyuan;Zhang Yingjun;S ·geerdeman CN108690016, 2018, A Location in patent:Paragraph 0366; 0368; 0369
82671-06-5
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113237-20-0
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96568-02-4
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113237-20-0
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100-70-9
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82671-02-1
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107-06-2
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113237-20-0
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113237-20-0
214 suppliers
$5.00/250mg