(2,6-Difluoro-4-methoxyphenyl)methanol synthesis
- Product Name:(2,6-Difluoro-4-methoxyphenyl)methanol
- CAS Number:79538-27-5
- Molecular formula:C8H8F2O2
- Molecular Weight:174.14
256417-10-4
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$11.00/1g
79538-27-5
21 suppliers
$150.00/5G
Yield:79538-27-5 95%
Reaction Conditions:
with sodium tetrahydroborate in methanol at 20; for 1 h;
Steps:
56.2 Step2:
Step2: To a cold stirring solution of 2,6-difluoro-4-methoxybenzaldehyde (2.3 g, 13.37 mmol, 1 eq) in MeOH (68 ml) was portion wise added NaBFE (0.65 g, 17.11 mmol, 1.28 eq). The reaction mixture was then stirred for 1 h at RT. The reaction mixture was then quenched by addition of ice (10 g). The solvents were evaporated and the residue was dissolved in EtOAc (100 ml) and washed by water (2 x 50 ml) followed by brine (100 ml). The organic layer was dried over anhydrous Na2S04, concentrated under reduced pressure to get (2,6-difluoro-4-methoxyphenyl)MeOH (2.2 g, 95%) as off white solid.
References:
WO2019/170904,2019,A1 Location in patent:Page/Page column 69-73
84937-82-6
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$22.00/100mg
79538-27-5
21 suppliers
$150.00/5G
79538-28-6
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$13.00/250mg
79538-27-5
21 suppliers
$150.00/5G