2,6-difluorobenzene-1-carbothioamide synthesis
- Product Name:2,6-difluorobenzene-1-carbothioamide
- CAS Number:60230-33-3
- Molecular formula:C7H5F2NS
- Molecular Weight:173.18
18063-03-1
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Yield:60230-33-3 99%
Reaction Conditions:
with Lawessons reagent in toluene at 90; for 14 h;
Steps:
3 Synthesis of 2,6-difluorobenzothioamide
A solution of 2,6 difluorobenzamide (1 eq) and Lawesson's reagent (0.5 eq.) in toluene (0.2 M) was heated at 90° C. for 14 hours. Upon cooling the volatiles were removed in vacuo and purified by SiO2 chromatography (25% EtOAc/hexanes) yielding 2,6-difluorobenzothioamide as a light yellow solid (99%). LCMS (m/z): 174.1 (MH+); LC Rt=2.19 min.
References:
US2010/216839,2010,A1 Location in patent:Page/Page column 44
1897-52-5
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