ChemicalBook CAS DataBase List 2,6-Difluorobenzoyl isocyanate

2,6-Difluorobenzoyl isocyanate synthesis

13synthesis methods

Product Name:2,6-Difluorobenzoyl isocyanate
CAS Number:60731-73-9
Molecular formula:C8H3F2NO2
Molecular Weight:183.11

917-61-3 Synthesis

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Yield: 91.75%

Reaction Conditions:

with aluminum (III) chloride;toluene-4-sulfonic acid in diethylene glycol dimethyl ether at 50 - 60; for 8 h;

Steps:

3 Example 3
84.5g (1.3mol) sodium cyanate, 20g (0.15mol) aluminum trichloride, 10g p-toluenesulfonic acid,400g o-dichlorobenzene and 40g diethylene glycol dimethyl ether were placed in the reactor,The temperature was controlled at 50-60 ° C, and 176.5g (1mol) of 2,6-difluorobenzoyl chloride was added dropwise.After the dropwise addition, the reaction was maintained at 60 ° C for 8 hours, and the solvent was distilled off under reduced pressure.Continue to evaporate under reduced pressure to obtain 168g of 2,6-difluorobenzoyl isocyanate, GC purity 99.5%, yield 91.75%.

References:

Dalian Qikai Pharmaceutical Technology Co., Ltd.;Jiang Bin;Zhang Hongxue;Jiang Dianbao CN111004150, 2020, A Location in patent:Paragraph 0025-0026