2,6-DiMethyltetrahydro-2H-pyran-4-ol synthesis
- Product Name:2,6-DiMethyltetrahydro-2H-pyran-4-ol
- CAS Number:41866-70-0
- Molecular formula:C7H14O2
- Molecular Weight:130.18
1073-79-6
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Yield:41866-70-0 98%
Reaction Conditions:
with sodium tris(acetoxy)borohydride;acetic acid in 1,2-dichloro-ethane at 20; for 20 h;
Steps:
5.1 Step 1: 2,6-dimethyltetrahydro-2H-pyran-4-ol:
To a solution of 2,6-dimethyldihydro-2H-pyran-4(3H)-one (3 g, 23.41 mmol) in DCE (60 mL) was added sodium triacetoxyborohydride (14.88 g, 70.2 mmol) followed by the addition of acetic acid (8.1 mL, 140 mmol) and the reaction mixture was stirred at room temperature for 20 h. The reaction was quenched with water and extracted with Et20 (3 x 50 mL). The organics were washed with brine, dried over MgSO4 , filtered and concentrated to give the desired product 2,6-dimethyltetrahydro-2H-pyran-4-ol as a colorless oil (3 g, 23.04 mmol, 98% yield).
References:
TWI609011,2017,B Location in patent:Page/Page column 73
1004-36-0
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