2,7-DICHLORO-1,8-NAPHTHYRIDINE synthesis
- Product Name:2,7-DICHLORO-1,8-NAPHTHYRIDINE
- CAS Number:55243-02-2
- Molecular formula:C8H4Cl2N2
- Molecular Weight:199.04
49655-93-8
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55243-02-2
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Yield:55243-02-2 74%
Reaction Conditions:
with phosphorus(V) chloride;trichlorophosphate for 6 h;Reflux;
Steps:
2,7-Dichloro-l,8-naphthyridine (4). S1-3
A mixture of 3 (1.10 g, 6.79 mmol), phosphorus pentachloride (3.00 g, 14.40 mmol), and phosphorus oxychloride (2.57 g, 16.76 mmol) was heated to reflux for 6 h. Then, the mixture was poured over crushed ice and the solution was made alkaline with sodium carbonate until the value of pH reached 8. A brown precipitate was collected and recrystallized from acetone to give 4 as a pale yellow powder (1.00 g, 5.08 mmol, 74%). 1H-NMR (500 MHz, DMSO-d6) δ 8.63 (d, J = 8.5 Hz, 2 H), 7.81 (d, J = 8.5 Hz, 2 H).
References:
Gao, Lianxun;Hao, Xueyu;Jin, Rizhe;Kang, Chuanqing;Li, Chunjie;Ma, Xiaoye;Wang, Liangpeng;Wang, Yu [Bioorganic and Medicinal Chemistry,2021,vol. 48,art. no. 116416] Location in patent:supporting information
106582-47-2
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55243-02-2
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141-86-6
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1931-44-8
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55243-02-2
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15944-33-9
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55243-02-2
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