ChemicalBook CAS DataBase List 2,7-DICHLORO-1,8-NAPHTHYRIDINE

2,7-DICHLORO-1,8-NAPHTHYRIDINE synthesis

6synthesis methods

Product Name:2,7-DICHLORO-1,8-NAPHTHYRIDINE
CAS Number:55243-02-2
Molecular formula:C8H4Cl2N2
Molecular Weight:199.04

49655-93-8
32 suppliers
$100.00/0.25/ G

55243-02-2
83 suppliers
$70.00/100mg

Yield:55243-02-2 74%

Reaction Conditions:

with phosphorus(V) chloride;trichlorophosphate for 6 h;Reflux;

Steps:

2,7-Dichloro-l,8-naphthyridine (4). S1-3

A mixture of 3 (1.10 g, 6.79 mmol), phosphorus pentachloride (3.00 g, 14.40 mmol), and phosphorus oxychloride (2.57 g, 16.76 mmol) was heated to reflux for 6 h. Then, the mixture was poured over crushed ice and the solution was made alkaline with sodium carbonate until the value of pH reached 8. A brown precipitate was collected and recrystallized from acetone to give 4 as a pale yellow powder (1.00 g, 5.08 mmol, 74%). 1H-NMR (500 MHz, DMSO-d6) δ 8.63 (d, J = 8.5 Hz, 2 H), 7.81 (d, J = 8.5 Hz, 2 H).

References:

Gao, Lianxun;Hao, Xueyu;Jin, Rizhe;Kang, Chuanqing;Li, Chunjie;Ma, Xiaoye;Wang, Liangpeng;Wang, Yu [Bioorganic and Medicinal Chemistry,2021,vol. 48,art. no. 116416] Location in patent:supporting information

106582-47-2 Synthesis

106582-47-2
6 suppliers
inquiry

55243-02-2
83 suppliers
$70.00/100mg

References

141-86-6
489 suppliers
$6.00/5g

55243-02-2
83 suppliers
$70.00/100mg

References

1931-44-8
87 suppliers
$11.00/100mg

55243-02-2
83 suppliers
$70.00/100mg

References

15944-33-9
29 suppliers
$90.00/50mg

55243-02-2
83 suppliers
$70.00/100mg

References