2-ACETAMIDO-4-(CHLOROMETHYL)THIAZOLE synthesis
- Product Name:2-ACETAMIDO-4-(CHLOROMETHYL)THIAZOLE
- CAS Number:7460-59-5
- Molecular formula:C6H7ClN2OS
- Molecular Weight:190.6506
Yield:7460-59-5 71%
Reaction Conditions:
in acetone; for 5 h;Heating / reflux;
Steps:
52-1
A solution of 50 g (0.42 mol) acetyl thiourea and 108.5 g 1,3-dichloro-propan-2-one (0.84 mol) in 500 ml acetone is heated to reflux for 5 hours. All volatiles were removed in vacuo and the residue was taken up in 200 ml acetone. After addition of 600 ml of water the precipitate was collected, washed with 250 ml n-heptane and dried in vacuo at 40° C. Yield: 56.9 g (71%) white solid. 1H-NMR (400 MHz, D6-DMSO): δ=2.13 (s, 3H); 4.71 (s, 2H); 7.22 (s, 1H); 12.21 (s, 1H)
References:
US2006/116407,2006,A1 Location in patent:Page/Page column 22
59608-97-8
114 suppliers
$17.00/500mg
75-36-5
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$17.92/100G
7460-59-5
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$28.60/50mg
7250-84-2
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$25.00/1g
108-24-7
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$14.00/250ML
7460-59-5
31 suppliers
$28.60/50mg
59608-97-8
114 suppliers
$17.00/500mg
108-24-7
5 suppliers
$14.00/250ML
7460-59-5
31 suppliers
$28.60/50mg