ChemicalBook CAS DataBase List 2-ACETYL-4-CHLOROTHIOPHENE

2-ACETYL-4-CHLOROTHIOPHENE synthesis

4synthesis methods

Product Name:2-ACETYL-4-CHLOROTHIOPHENE
CAS Number:34730-20-6
Molecular formula:C6H5ClOS
Molecular Weight:160.62

88-15-3
591 suppliers
$5.00/10g

34730-20-6
172 suppliers
$9.00/250mg

Yield:34730-20-6 82.48%

Reaction Conditions:

with aluminum (III) chloride;trichloroisocyanuric acid in dichloromethane at 10 - 15; for 4 h;

Steps:

1
As shown in the formula (II), 200 g of 2-acetylthiophene Sm1 (1 eq) was dissolved in 2 L of dichloromethane, and 147.3 g of trichloroisocyanuric acid Sm2 (0.4 eq) was added.1060 g of aluminum trichloride (5 eq) was slowly added in portions at 10-15 °C.Add in 2 hours. Then react at 10-15 ° C for 2 h, the reaction was completed by TLC, and the reaction solution was flushed into 2 L of ice 1 M hydrochloric acid solution, dichloromethylAlkane extraction, drying the organic phase with sodium sulfate, concentrating and distilling to obtain 210 g of 2-acetyl-4-chlorothiophene in a yield of 82.48%.

References:

Shanghai Bide Pharmaceutical Technology Co., Ltd.;Chen Hua;Li Ronghao;Kang Zhijun CN109369611, 2019, A Location in patent:Paragraph 0035-0037

FullText