2-amino-2-(3-bromophenyl)acetamide synthesis

Yield:-

Reaction Conditions:

with ammonia in water at 20; for 18 h;

Steps:

21

A mixture of methyl amino(3-bromophenyl)acetate (D20) (2.35g) in 0.88 NH₃ solution (50ml) at room temperature under argon was stirred well for 18 hours affording a homogeneous solution, which was then extracted with DCM (3 x 30ml) and the extract dried (Na₂SO₄) and concentrated under vacuum to leave the title compound as a white solid (1.51g).¹H NMR (D₆-DMSO) δ: 2.23 (2H, s), 4.30 (1 H, s), 7.08 (1 H, s), 7.26 (1 H, m), 7.40-7.46 (2H, m), 7.51 (1 H, s), 7.60 (1 H, s).

References:

WO2009/34061,2009,A1 Location in patent:Page/Page column 45