2-Amino-2-(4-bromo-phenyl)-acetamide synthesis
- Product Name:2-Amino-2-(4-bromo-phenyl)-acetamide
- CAS Number:950651-22-6
- Molecular formula:C8H9BrN2O
- Molecular Weight:229.07
42718-20-7
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Yield:950651-22-6 85%
Reaction Conditions:
with ammonium hydroxide at 10 - 15; for 20 h;Large scale;
Steps:
1
[0073] Precursor II (1.75 kg, 6.2 mol, 1.0 eq.) was charged into a 20 L reactor with NH3* H2O (28%, 8.8 L, 5 v). The mixture was stirred at 10-15 °C for 20 h, then filtered and the filter cake washed with water (3.5 L, 2 v). The filter cake was dried under reduced pressure at 50 °C to obtain Precursor III (2-amino-2-(4-bromophenyl)acetamide) with 96 A% purity in an 85% isolated yield.
References:
WO2022/81514,2022,A1 Location in patent:Paragraph 0071; 0073
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