2-Amino-2-phenylacetic acid synthesis
- Product Name:2-Amino-2-phenylacetic acid
- CAS Number:2835-06-5
- Molecular formula:C8H9NO2
- Molecular Weight:151.17
611-73-4
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$36.00/5g
2835-06-5
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$6.00/25g
Yield:2835-06-5 95%
Reaction Conditions:
with ammonium formate;Cp*IrCl(N-(4'-methoxyphenyl)-2-pyridinecarboxamide) complex in methanol at 60; for 1.5 h;Inert atmosphere;Schlenk tube;
Steps:
28 Synthesis of DL-2-phenylglycine
Examples 28 Synthesis of DL-2-phenylglycine 751 mg (5.0 mmol) of benzoyl formate (MW: 150.13), 946 mg (15.0 mmol) of ammonium formate (MW: 63.06), and 5.90 mg (0.01 mmol, S/C=500) of the iridium catalyst Ir-7 (MW: 590.13) were introduced in a 20-mL Schlenk tube and subjected to argon-gas replacement. 5 mL of dehydrated methanol was added and the mixture was stirred while heating at 60° C. for 1.5 hr. After distillation of the solvent, a crystal was collected by filtration, washed with methanol, dried under reduced pressure to give 718 mg of DL-2-phenylglycine (95% yield).
References:
Kanto Kagaku Kabushiki Kaisha US2010/234596, 2010, A1 Location in patent:Page/Page column 14
4870-65-9
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2835-06-5
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89-24-7
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$14.14/250mgs:
2835-06-5
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2973-50-4
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$11.00/250mg
2835-06-5
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2935-35-5
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$5.00/10g
2835-06-5
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$6.00/25g