2-AMino-6-(benzylaMino)-3-nitropyridine synthesis
- Product Name:2-AMino-6-(benzylaMino)-3-nitropyridine
- CAS Number:21626-43-7
- Molecular formula:C12H12N4O2
- Molecular Weight:244.25
27048-04-0
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Yield:21626-43-7 93.8%
Reaction Conditions:
with potassium carbonate in N,N-dimethyl-formamide at 80; for 19 h;
Steps:
3.7.1. N6-Benzyl-3-nitro-pyridine-2,6-diamine (3-b)
To a solution of 2-amino-6-chloro-3-nitropyridine (1.0 equiv.) and benzylamine (2.0 equiv.) inDMF was added K2CO3 (5.0 equiv.). The reaction mixture was stirred at 80 °C for 19 hr. After cooling atroom temperature, H2O was slowly added to the reaction mixture. The solid was filtered and washedwith H2O. Yield: 93.8%, 1H-NMR (300 MHz, DMSO-d6) δ 4.59 (s, 2H), 6.01 (d, J = 9.2 Hz, 1H), 7.26 (m,1H), 7.34 (m, 4H), 7.80 (br. s, 1H), 7.96 (d, J = 9.2 Hz, 1H), 8.12 (br. s, 1H), 8.39 (br. s, 1H); 13C-NMR(75 MHz, DMSO-d6) δ 43.80, 102.38, 117.50, 126.99, 127.67, 128.37, 134.46, 139.00, 155.78, 160.46.
References:
Lee, Myeong Hwi;Balupuri, Anand;Jung, Ye-rim;Choi, Sungwook;Lee, Areum;Sik Cho, Young;Sook Kang, Nam [Molecules,2018,vol. 23,# 12,art. no. 3136]
16013-85-7
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