(2-amino-6-methylphenyl)methanol synthesis
- Product Name:(2-amino-6-methylphenyl)methanol
- CAS Number:65658-16-4
- Molecular formula:C8H11NO
- Molecular Weight:137.18
4389-50-8
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65658-16-4
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$130.00/50mg
Yield:65658-16-4 97%
Reaction Conditions:
with lithium aluminium tetrahydride in tetrahydrofuran at 0 - 20; for 2 h;
Steps:
1 Synthesis of Compound 71 (4-((3,5-dimethylisoxazol-4-yl)methoxy)-N-(2-(hydroxymethyl)-3-methylphenyl)benzamide)
To a stirred solution of 2-Amino-6-methyl-benzoic acid (15) (1.0 g, 5.58 mmol) in THF (20 mL) was added LiAlH4 powder (0.848 g, 22.319 mmol) at 0°C and the resultant mixture was stirred at room temperature for 2 hours. Reaction mixture was then quenched with water, stirred for 30 minutes and filtered. Filtrate was diluted with EtAOc, washed with water, brine, dried over sodium sulfate and concentrated under reduced pressure to afford desired intermediate 16 (750 mg, 97%) as yellow gum.
References:
WO2018/175324,2018,A1 Location in patent:Page/Page column 105
54915-41-2
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65658-16-4
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65658-16-4
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13506-76-8
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65658-16-4
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65658-16-4
28 suppliers
$130.00/50mg