ChemicalBook CAS DataBase List 2-Aminobenzothiazole-6-carboxylic acid

2-Aminobenzothiazole-6-carboxylic acid synthesis

13synthesis methods

Product Name:2-Aminobenzothiazole-6-carboxylic acid
CAS Number:93-85-6
Molecular formula:C8H6N2O2S
Molecular Weight:194.21

540-72-7 Synthesis

540-72-7
398 suppliers
$13.50/100G

150-13-0 Synthesis

150-13-0
876 suppliers
$5.00/25g

93-85-6
148 suppliers
$7.00/250mg

Yield:93-85-6 42%

Reaction Conditions:

with bromine in methanol at -10 - -5; for 2 h;

Steps:

1
Synthesis of 2-aminobenzothiazole-6-carbolic Acid(2)NaSCN (65 g, 0.8 mol) was added to a suspension of commercially available 4-amino-benzoic acid (1, 100 g, 0.73 mol) in MeOH followed by the addition of Br₂(38 ml, 0.73 mol) in portions. The above solution was allowed to cool to -10° C. and stirred for 2 h while keeping the inner temperature below -5° C. The precipitate was then filtered and suspended in 350 ml of 1 M HCl. The suspension was heated to reflux for 30 min. After immediate filtration, 150 ml concd HCl was added to the hot filtrate to give 70 g (yield 42%) of 2-amino-benzothiazole-6-carboxylic acid (2) (as a white solid), which was dried and used without further purification.

References:

WANG, YANMING;Wu, Chunying US2009/123373, 2009, A1 Location in patent:Page/Page column 14-15

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68867-21-0 Synthesis