(2-AMINOTHIAZOL-4-YL)METHANOL synthesis
- Product Name:(2-AMINOTHIAZOL-4-YL)METHANOL
- CAS Number:51307-43-8
- Molecular formula:C4H6N2OS
- Molecular Weight:130.17
38987-72-3
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17356-08-0
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51307-43-8
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Yield:51307-43-8 80%
Reaction Conditions:
in ethanol for 1.5 h;Heating / reflux;
Steps:
10; 11; 12
1-Bromo-3-hydroxypropan-2-one (60 g, 392 mmol) and thiourea (34 g, 451 mmol) were charged into a 1 L round bottom flask containing 400 mL of EtOH. The resulting mixture was heated to reflux for 90 minutes. The reaction mixture was then cooled and concentrated under reduced pressure, and a precipitate formed. The product was obtained as a solid (40 g, yield=80%) after filtration and washing three times with hexane. The product was used directly in the next step without further purification. LCMS (API-ES) m/z (%) 131.2 (100%, M++H).
References:
AMGEN INC. US2007/173506, 2007, A1 Location in patent:Page/Page column 34
5398-36-7
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51307-43-8
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$30.00/250mg
59608-97-8
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51307-43-8
115 suppliers
$30.00/250mg
