2-BENZYLOXY-6-CHLORO-ISONICOTINIC ACID synthesis
- Product Name:2-BENZYLOXY-6-CHLORO-ISONICOTINIC ACID
- CAS Number:182483-63-2
- Molecular formula:C13H10ClNO3
- Molecular Weight:263.68
Yield:-
Reaction Conditions:
Stage #1: benzyl alcoholwith sodium hydride in N,N-dimethyl-formamide at 0; for 1 h;
Stage #2: 2,6-dichloropyridine-4-carboxylic acid in N,N-dimethyl-formamide at 0 - 90;
Steps:
63
With cooling with ice, benzyl alcohol (3.4 mL) was dropwise added to a DMF (100 mL) suspension of sodium hydride (3.2 g). This was stirred at that temperature for 1 hour, then a DMF (30 mL) solution of 2,6-dichloropyridine-4-carboxylic acid (6.38 g) was dropwise added to the reaction solution with cooling with ice, and stirred at that temperature for 1 hour and 30
References:
WO2008/88692,2008,A2 Location in patent:Page/Page column 125
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