2-(benzyloxy)isoquinoline-1,3(2H,4H)-dione synthesis
- Product Name:2-(benzyloxy)isoquinoline-1,3(2H,4H)-dione
- CAS Number:611187-05-4
- Molecular formula:C16H13NO3
- Molecular Weight:267.28
Yield:611187-05-4 97%
Reaction Conditions:
in toluene; for 12 h;Reflux;Inert atmosphere;
Steps:
1.1a Step 1a: Preparation of 2-(benzyloxy)isoquinoline-1,3(2H,4H)-dione:
2-(Carboxymethyl)benzoic acid (180 mg, 1 mmol) and O-benzylhydroxylamine (148 mg, 1.2 mmol) were dissolved in 250 mL of toluene, connected to a water separator, and reacted under reflux for 12 h. After the reaction solution was filtered, concentrated under reduced pressure to obtain a crude product,The crude product was purified by silica gel column chromatography to give 2-(benzyloxy)isoquinoline-1,3(2H,4H)-dione as a white solid(260 mg, yield: 97%)
References:
CN114539148,2022,A Location in patent:Paragraph 0075; 0079-0081; 0103
