2-bromo-[1,2,4]triazolo[1,5-a]pyridin-7-amine synthesis
- Product Name:2-bromo-[1,2,4]triazolo[1,5-a]pyridin-7-amine
- CAS Number:1380331-65-6
- Molecular formula:C6H5BrN4
- Molecular Weight:213.03
![(2-Bromo-[1,2,4]triazolo[1,5-a]pyridin-7-yl)-carbamic acid tert-butyl ester](/CAS/20180527/GIF/1380331-50-9.gif)
1380331-50-9
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Yield:1380331-65-6 67.7%
Reaction Conditions:
Stage #1: tert-butyl (2-bromo-[1,2,4]triazolo[1,5-a]pyridin-7-yl)carbamatewith hydrogenchloride in diethyl ether;dichloromethane at 25; for 18 h;
Stage #2: with sodium hydroxide in water; pH=14;
Steps:
65.b
b) 2-Bromo-[1,2,4]triazolo[1,5-a]pyridin-7-ylamine A suspension of tert-butyl 2-bromo-[1,2,4]triazolo[1,5-a]pyridin-7-ylcarbamate (5.19 g, 16.6 mmol) in dichloromethane (150 ml) and hydrochloric acid (5N in ether, 150 ml, 750 mmol) was stirred for 18 hours at 25° C. The solvents were evaporated, the residue was suspended in water (200 ml) and adjustetd to pH=14 using sodium hydroxide 32%. The precipitated solid was filtered off, washed with water 4 times and dried in vacuo affording 2-bromo-[1,2,4]triazolo[1,5-a]pyridin-7-ylamine (2.39 g, 67.7&) as a light yellow solid. MS: m/z=213.0/215.1 (M+H+).
References:
US2012/142665,2012,A1 Location in patent:Page/Page column 46
84249-14-9
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882521-63-3
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1380331-15-6
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