2-bromo-1-(4-bromo-3-fluorophenyl)ethanone synthesis
- Product Name:2-bromo-1-(4-bromo-3-fluorophenyl)ethanone
- CAS Number:1003879-02-4
- Molecular formula:C8H5Br2FO
- Molecular Weight:295.93
304445-49-6
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$8.00/100mg
1003879-02-4
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$138.00/250mg
Yield:1003879-02-4 44%
Reaction Conditions:
with copper(ll) bromide in ethyl acetate at 60; for 12 h;
Steps:
18a Step 18a.
A mixture of 1-(4-bromo-3-fluorophenyl)ethanone (1 g, 4.6 mmol), copper(II) bromide (2.1 g, 9.7 mmol) in EtOAc (50 mL) was stirred for 12 hours at 60° C. The mixture was allowed to cool down and filtered. The filtrate was concentrated. The residue was chromatographed (silica, ethyl acetate/petroleum ether) to give the desired compound as a yellow solid (600 mg, 44%).
References:
ENANTA PHARMACEUTICALS, INC.;Qiu, Yao-Ling;Cao, Hui;Li, Wei;Kass, Jorden;Gao, Xuri;Peng, Xiaowen;Jin, Meizhong;Or, Yat Sun US2016/289212, 2016, A1 Location in patent:Paragraph 0270
695188-21-7
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18107-18-1
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1003879-02-4
37 suppliers
$138.00/250mg
1260857-14-4
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$397.00/1g
153556-42-4
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$10.00/1g
1003879-02-4
37 suppliers
$138.00/250mg
343564-56-7
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1003879-02-4
37 suppliers
$138.00/250mg