2-broMo-3-fluoro-6-nitrobenzoic acid synthesis
- Product Name:2-broMo-3-fluoro-6-nitrobenzoic acid
- CAS Number:881415-27-6
- Molecular formula:C7H3BrFNO4
- Molecular Weight:264.01
132715-69-6
242 suppliers
$15.00/2 g
881415-27-6
23 suppliers
inquiry
Yield:-
Reaction Conditions:
with sulfuric acid;nitric acid in neat (no solvent) at 0 - 20; for 16 h;
Steps:
4 Step 1 : Preparation of2-bromo-3-fluoro-6-nitrobenzoic acid
To a solution of 2-bromo-3-fluorobenzoic acid (2 g, 9.17 mmol) in H2S04 (8 mL) was added HN03 (0.8 mL, 9.17 mmol) at 0 °C. The reaction mixture was stirred for 16 hours at room temperature and was poured onto ice. The solid was isolated by filtration and purified by column chromatography to afford 2-bromo-3-fluoro-6-nitrobenzoic acid (500 mg, 20%, LC-MS 92%) as a pale yellow solid. NMR (400 MHz, DMSO-< δ (ppm): 8.35 (dd, / = 5.2 Hz, 9.6 Hz, 1H), 7.74-7.66 (m, 1H); MS (ESI) m/z: 263.9 [C7H3BrFN04-H]+.
References:
AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH;NACRO, Kassoum WO2018/21977, 2018, A1 Location in patent:Page/Page column 157
132715-69-6
242 suppliers
$15.00/2 g
881415-28-7
5 suppliers
inquiry
881415-27-6
23 suppliers
inquiry