2-Bromo-5-chloropyridin-3-ol synthesis

Yield:-

Reaction Conditions:

with bromine in sodium hydroxide

Steps:

60.a (a)
(a) 2-bromo-5-chloro-3-pyridinol A solution of bromine (12.35 g) in 10% NaOH (70 mL) was added dropwise with stirring to a solution of 5-chloro-3-pyridinol (10.00 g) in 10% NaOH (70 mL). After the addition was complete, the reaction was stirred at 22° C. for 20 h. The reaction was cooled to 0° C. and acidified to pH 5.3 with concentrated HCl (aq). The precipitate was filtered and dried under vacuum for 60 h to afford a) (15.66 g, 97%).

References:

Bristol-Myers Squibb Company US4954502, 1990, A