2-bromo-3-nitro-1-benzothiophene synthesis

Yield:100949-37-9 97%

Reaction Conditions:

with nitric acid;acetic acid at 60; for 0.5 h;

Steps:

3.1 Preparation of Compound 3-6

2-Bromo-benzo [b] thiophene (2-bromobenzo [b] thiophene) 10g (46.9mmol), fuming nitric acid (fuming HNO₃(100%) 4mL, 30 minutes after the mixed solution in 1.5L AcOH 60 It was stirred. after the reaction was completed by recrystallization distilled water at room temperature to give 11.7g of the desired compound 3-6 (97%).

References:

KR2016/51212,2016,A Location in patent:Paragraph 0127-0129