2-BROMO-4-ETHOXY-1-(TRIFLUOROMETHOXY)BENZENE synthesis

Yield:1049730-92-8 80%

Reaction Conditions:

with potassium carbonate in acetone; for 12 h;Heating / reflux;

Steps:

23

Preparation 23 2-Bromo-4-ethoxy-1-trifluoromethoxv-benzene To a solution of the 3-bromo-4-trifluoromethoxyphenol (1.0 g, 2.48 mmol) in acetone (30 ml) was added ethyl iodide (0.795 ml, 9.94 mmol) followed by potassium carbonate (1.37 g, 9.94 mmol) and resulting solution was heated to reflux for 12hrs. The reaction mixture was cooled then filtered and concentrated in vacuo. Dichloromethane (20 ml) and water (20 ml) were added and the solution was filtered through a phase separation cartridge. The organic layer was collected, and evaporated in vacuo to afford crude title compound as a colourless oil (884 mg, 80%). Material was taken on without further purification.¹H-NMR (d₆-DMSO) 1 H: 1.25 (t, 3H), 4.05 (q, 2H)₁ 7.00 (dd, 1 H), 7.35 (d, 1 H), 7.40 (dd, 1H). LCMS (2 min) Rt = 1.82 minMS m/z 286 [MH]+

References:

WO2008/135830,2008,A1 Location in patent:Page/Page column 66-67