2-bromo-4-methylthiazole-5-carbaldehyde synthesis
- Product Name:2-bromo-4-methylthiazole-5-carbaldehyde
- CAS Number:933720-87-7
- Molecular formula:C5H4BrNOS
- Molecular Weight:206.06
40003-41-6
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Yield:933720-87-7 68 %
Reaction Conditions:
with 4-piperidinylpyridine;trifluoromethanesulfonylpyridinium salt;pinacolborane in dichloromethane at 20;Inert atmosphere;Schlenk technique;
Steps:
31 Example 31
2-Bromo-4-methylthiazole-5-carboxylic acid (1.0 mmol, 220.9 mg) was added to a 25 mL Schlenk tube under nitrogen atmosphere,1-Pyridine-4-piperidine (1.6 mmol, 259.2 mg) and 5 mL of dichloromethane were added sequentially at short intervals, followed by the addition of trifluoromethanesulfonyl pyridinium salt PPDP-Tf (1.7 mmol, 755 mg) and HBpin ( 1.1mmol, 140.8mg), stirred for 10min.After the reaction, add aqueous solution and dichloromethane (3 × 5mL) to the system for extraction, column chromatography separation to obtain the product aldehyde compound,The yield was 68%.
References:
CN114933511,2023,B Location in patent:Paragraph 0169-0172; 0330
933782-03-7
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22900-83-0
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