2-bromo-4-octyl-Thiophene synthesis

Yield:189102-85-0 92%

Reaction Conditions:

Stage #1: 3-octylthiophenewith n-butyllithium in tetrahydrofuran;hexane at -78; for 2.5 h;Inert atmosphere;
Stage #2: with bromine in tetrahydrofuran;hexane at -78; for 0.583333 h;Inert atmosphere;regioselective reaction;

References:

El-Shehawy, Ashraf A.;Abdo, Nabiha I.;El-Barbary, Ahmed A.;Lee, Jae-Suk [Tetrahedron Letters,2010,vol. 51,# 34,p. 4526 - 4529] Location in patent:supporting information; experimental part