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2-BroMo-5-cyclopropylpyrazine synthesis

1synthesis methods
23229-26-7 Synthesis
2,5-Dibromopyrazine

23229-26-7
229 suppliers
$10.00/1g

411235-57-9 Synthesis
Cyclopropylboronic acid

411235-57-9
426 suppliers
$6.00/1g

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Yield: 45%

Reaction Conditions:

with dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2;caesium carbonate in water;toluene for 0.5 h;Reflux;Inert atmosphere;

References:

Lucas-Hourani, Marianne;Munier-Lehmann, Hélène;El Mazouni, Farah;Malmquist, Nicholas A.;Harpon, Jane;Coutant, Eloi P.;Guillou, Sandrine;Helynck, Olivier;Noel, Anne;Scherf, Artur;Phillips, Margaret A.;Tangy, Frédéric;Vidalain, Pierre-Olivier;Janin, Yves L. [Journal of Medicinal Chemistry,2015,vol. 58,# 14,p. 5579 - 5598]