2-broMo-6-(4-Methoxyphenyl)pyridine synthesis
- Product Name:2-broMo-6-(4-Methoxyphenyl)pyridine
- CAS Number:193344-39-7
- Molecular formula:C12H10BrNO
- Molecular Weight:264.12
626-05-1
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21172-80-5
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Yield:193344-39-7 77 %Spectr. ，21172-80-5 7 %Spectr.
Reaction Conditions:
with potassium carbonate in tetrahydrofuran;water at 30; for 28 h;chemoselective reaction;Suzuki-Miyaura Coupling;
Steps:
Suzuki-Miyaura coupling reaction of 2,6-dibromopyridine (5) with 4-methoxyphenylboronic acid using PS-PdMC as catalyst (Table 1, Entries 2 and 3)
A mixture of 2,6-dibromopyridine (5) (7.6 mg, 0.032 mmol), 4-methoxyphenylboronic acid (9.7 mg, 0.064 mmol, 2.0 eq.), PS-PdMC (3.1 mg, 5 mol% for Pd atom), and K2CO3 (18 mg, 0.13 mmol) in THF (0.2 mL) and H2O (0.2 mL) was stirred at 30 °C for 28 h. The resulting crude mixture was filtrated to recover PS-PdMC and washed with the same solvent and CHCl3/MeCN (1/1) in this order. The filtrate was added to water, and the aqueous phase was extracted with CHCl3 three times. The combined organic phase was washed with water, dried over anhydrous MgSO4, and concentrated under reduced pressure. The yields of 5, 6,2 and 72 were determined by 1H NMR using 1,1,2,2,-tetrachloroethane as an internal standard. The recovered PS-PdMC was dried under reduced pressure and applied to the same reaction condition.
References:
Yamamoto, Koji;Nameki, Riku;Sogawa, Hiromitsu;Takata, Toshikazu [Tetrahedron Letters,2020,vol. 61,# 21,art. no. 151870] Location in patent:supporting information
626-05-1
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254454-47-2
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193344-39-7
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696-62-8
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651358-83-7
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193344-39-7
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5720-07-0
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234111-08-1
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