2-broMo-6-cyclopropylpyridine synthesis
- Product Name:2-broMo-6-cyclopropylpyridine
- CAS Number:1086381-26-1
- Molecular formula:C8H8BrN
- Molecular Weight:198.06
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Yield:1086381-26-1 44%
Reaction Conditions:
with tetrakis(triphenylphosphine) palladium(0);caesium carbonate in 1,4-dioxane at 100; for 1 h;Inert atmosphere;
Steps:
7.1 Step 1: 2-Bromo-6-cyclopropylpyridine (1)
[00286] A stirred mixture of 2,6-dibromopyridine (1.9 g, 8.08 mmol), cyclopropylboronic acid (1.37 g, 16.17 mmol), Cs2C03 (7.8 g, 24.2 mmol), Pd(PPh3)4 (464 mg, 0.401 mmol), and 1,4- dioxane (32 mL) under an inert atmosphere, was heated at 100 °C for 1 h. The mixture was cooled to rt and filtered through a pad of celite, and the celite further washed with EtOAc (2 χ 75 mL). The filtrate was concentrated under reduced pressure and the residue was purified (silica gel; eluting with 100% hexanes) to afford compound 1 (700 mg, 44%) as a pale brown solid. 1H MR (400 MHz, CDC13): δ 7.36 (m, 1H), 7.20 (m, 1H), 7.04 (m, 1H), 1.98 (m, 1H), 0.96 - 1.05 (m, 4H); LCMS Mass: 199.7 (M++l).
References:
WO2018/183122,2018,A1 Location in patent:Paragraph 00285; 00286; 00287
626-05-1
511 suppliers
$9.00/10g
1086381-26-1
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626-05-1
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1065010-87-8
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