2-Bromo-N-methyl-5-(trifluoromethyl)aniline synthesis
2synthesis methods
- Product Name:2-Bromo-N-methyl-5-(trifluoromethyl)aniline
- CAS Number:1187395-73-8
- Molecular formula:C8H7BrF3N
- Molecular Weight:254.05
Yield:1187395-73-8 81%
Reaction Conditions:
Stage #1: 2-Bromo-5-trifluoromethylanilinewith methyllithium in tetrahydrofuran;diethyl ether at -78; for 1 h;Inert atmosphere;
Stage #2: methyl iodide in tetrahydrofuran at -78 - 20;Inert atmosphere;
References:
Probst, Nicolas;Grelier, Gwendal;Ghermani, NourEddine;Gandon, Vincent;Alami, Mouad;Messaoudi, Samir [Organic Letters,2017,vol. 19,# 19,p. 5038 - 5041] Location in patent:supporting information
