2-BROMO-N,N-DIMETHYL-4-FLUOROANILINE synthesis

1synthesis methods

Product Name:2-BROMO-N,N-DIMETHYL-4-FLUOROANILINE
CAS Number:887268-19-1
Molecular formula:C8H9BrFN
Molecular Weight:218.07

Benzenamine, 4-fluoro-N,N-dimethyl-, N-oxide

130445-20-4
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887268-19-1
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Yield:887268-19-1 26%

Reaction Conditions:

Stage #1: 4-Fluoro-N,N-dimethylaniline N-oxidewith sulfurous dibromide in tetrahydrofuran at -78; for 4 h;Inert atmosphere;
Stage #2: with triethylamine in tetrahydrofuran at -78 - 23; for 0.75 h;Inert atmosphere;regioselective reaction;

References:

Reed, Hayley;Paul, Tyler R.;Chain, William J. [Journal of Organic Chemistry,2018,vol. 83,# 18,p. 11359 - 11368]