2-(bromomethyl)-5-methylthiazole synthesis

Yield:221020-96-8 76.9%

Reaction Conditions:

with N-Bromosuccinimide;dibenzoyl peroxide in tetrachloromethane; for 4 h;Reflux;

Steps:

22 2-(bromomethyl)-5-methylthiazole

To a solution of 2,5-dimethylthiazole (200 mg, 1.77 mmol) in carbon tetrachloride (5 mL) was added NBS (377 mg, 2.12 mmol), followed by BPO (20 mg, 0.083 mmol).
Then the mixture was heated to reflux for 4 h with stirring.
The mixture was cooled to room temperature and filtered, the filtrate was concentrated to give crude product 2-(bromomethyl)-5-methylthiazole (260 mg, 76.9%) as yellow oil, which was used without purification.

References:

US2014/275528,2014,A1 Location in patent:Paragraph 0301; 0302