2-Chloro-1-ethoxy-4-nitrobenzene synthesis
- Product Name:2-Chloro-1-ethoxy-4-nitrobenzene
- CAS Number:5493-71-0
- Molecular formula:C8H8ClNO3
- Molecular Weight:201.61
Yield: 61.8%
Reaction Conditions:
with potassium carbonate in N,N-dimethyl-formamide at 80; for 16 h;
Steps:
92.a a) 2- (2-Chloro-4-nitrophenoxy) ethyl-1-yl
Dissolve 2-chloro-4-nitrophenol (1.74g, 10mmol) and potassium carbonate (6.9g, 50mmol) in DMF (30mL), add 2-bromoethanol (2.2mL, 30mmol) and raise the temperature to 80 ° C. The reaction 16h. Concentrate, add EA (20 mL × 2), extract with water (10 mL), combine the organic phase with anhydrous magnesium sulfate and dry to obtain 1.345 g of yellow-white solid, yield 61.8%, melting point: 111-112 ° C.
References:
Chinese Academy Of Medical Sciences Pharmaceutical Institute;Xu Boling;Chen Xiaoguang;Cui Guonan;Lai Fangfang;Zhou Jie;Ji Ming;Wang Xiaoyu;Du Tingting;Li Ling;Jin Jing CN110483366, 2019, A Location in patent:Paragraph 1331-1336
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1000210-73-0
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5493-71-0
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$91.00/1g
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5493-71-0
13 suppliers
$91.00/1g