2-chloro-5,6,7,8-tetrahydro-4(3H)-Quinazolinone synthesis
- Product Name:2-chloro-5,6,7,8-tetrahydro-4(3H)-Quinazolinone
- CAS Number:178308-51-5
- Molecular formula:C8H9ClN2O
- Molecular Weight:184.62
1127-85-1
102 suppliers
$14.00/250mg
178308-51-5
10 suppliers
$51.00/25mg
Yield:178308-51-5 91%
Reaction Conditions:
with sodium hydroxide in tetrahydrofuran at 60; for 12 h;Inert atmosphere;
Steps:
7.3 Step 3) Synthesis of 2-chloro-5,6,7,8_tetrahydroquinazolin_4 (3Η)-one
The title compound in this step was prepared according to the method described in step 4 of Example 4, ie, 2,4_dichloro_5,6,7,8-tetrahydroquinazoline (3.21 g, 15.8 lmmo 1) and sodium hydroxide solution (100mL, 1mol/L) and tetrahydrofuran (12mL)Reaction at 60°C for 12h. The obtained crude product was separated and purified by silica gel column chromatography (petroleum ether/ethyl acetate (ν/ν) = 4/1) to obtain the standardThe title compound (white solid, 2.61g, 91%).
References:
CN108299437,2018,A Location in patent:Paragraph 0291; 0301-0304
35042-48-9
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$45.00/25mg
178308-51-5
10 suppliers
$51.00/25mg
1655-07-8
309 suppliers
$6.00/5g
178308-51-5
10 suppliers
$51.00/25mg