2-Chloro-6,7-dihydrobenzo[b]thiophen-4(5H)-one synthesis
- Product Name:2-Chloro-6,7-dihydrobenzo[b]thiophen-4(5H)-one
- CAS Number:22168-07-6
- Molecular formula:C8H7ClOS
- Molecular Weight:186.6586
13414-95-4
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Yield:22168-07-6 62%
Reaction Conditions:
with N-chloro-succinimide;acetic acid at 50;
Steps:
10.1; 14.1 Step 1. 2-Chloro-6,7-dihydrobenzo [b] thiophene-4 (5H) -one (Compound 2)
To 6,7-dihydrobenzo [b] thiophene-4 (5H) -one (25g, 0.16mol)Acetic acid (50mL)To the solution was added N-chlorosuccinimide (32 g, 0.24 mol),The reaction mixture was heated to 50 ° C and reacted overnight.Cool to room temperature, concentrate, extract by adding water and ethyl acetate, and dry over anhydrous sodium sulfate,Filtration and concentration, the residue was purified by column chromatography to obtain compound 2 (19 g, yield: 62%).
References:
CN110511220,2019,A Location in patent:Paragraph 0346-0350; 0421-0425
70685-06-2
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22168-07-6
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