2-CHLORO-6-FLUOROBENZYLAMINE synthesis
- Product Name:2-CHLORO-6-FLUOROBENZYLAMINE
- CAS Number:15205-15-9
- Molecular formula:C7H7ClFN
- Molecular Weight:159.59
55117-15-2
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$9.00/1g
15205-15-9
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Yield:-
Reaction Conditions:
with ammonia in benzene
Steps:
2 Preparation of 2 -Chloro-6 -fluorobenzylamine
EXAMPLE 2 Preparation of 2 -Chloro-6 -fluorobenzylamine An autoclave was charged with 89.0 g. (0.5 mole) of 2-chloro-6-fluorobenzyl chloride, 170.0 g. (10 mole) ammonia and 50 ml. benzene. The reaction vessel was sealed and the contents heated at 100° C. for 15 hours. The excess ammonia was carefully evaporated off from the cooled contents of the autoclave with a stream of nitrogen. The residue was washed with water, and the organic phase after drying with anhydrous MgSO4, fractionated to afford 72.4 g. (90%) of product as a clear liquid; b.p. 99°-100° C./20 mm; NMR (CDCl3) δ 1.46 (s, 2H); 3.88 (d, 2H); 7.00 (m, 3H).
References:
Merck & Co., Inc. US4098787, 1978, A
668-45-1
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15205-15-9
116 suppliers
$9.00/1g