2-CHLORO-6-(TRIFLUOROMETHYL)NICOTINAMIDE synthesis
- Product Name:2-CHLORO-6-(TRIFLUOROMETHYL)NICOTINAMIDE
- CAS Number:386704-05-8
- Molecular formula:C7H4ClF3N2O
- Molecular Weight:224.57
386704-06-9
126 suppliers
$11.00/250mg
386704-05-8
74 suppliers
$11.00/100mg
Yield:-
Reaction Conditions:
with sulfuric acid at 75; for 2 h;
Steps:
5
EXAMPLE 5 Preparation (2) of 2-chloro-6-trifluoromethylnicotinamide To 100 g of 2-chloro-6-trifluoromethylnicotinonitrile, 140 mL of 96 vol% sulfuric acid was added, followed by stirring at 75°C for 2 hours. A reaction solution was poured in 500 mL of cooled water, and precipitated crystals were collected by filtration, washed with water and dried to obtain 108 g of 2-chloro-6-trifluoromethylnicotinamide.
References:
ISHIHARA SANGYO KAISHA, LTD. EP2251329, 2010, A1 Location in patent:Page/Page column 5
1186306-84-2
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$134.31/250mgs:
386704-05-8
74 suppliers
$11.00/100mg