2-(CHLOROMETHYL)-5-METHYLPYRAZINE synthesis
- Product Name:2-(CHLOROMETHYL)-5-METHYLPYRAZINE
- CAS Number:81831-68-7
- Molecular formula:C6H7ClN2
- Molecular Weight:142.59
61892-95-3
87 suppliers
$21.00/100mg
81831-68-7
42 suppliers
$72.00/100 mg
Yield:-
Reaction Conditions:
with thionyl chloride in dichloromethane at 0 - 26; for 16 h;
Steps:
Intermediate 119: 2-(chloromethyl)-5-methylpyrazine:
To a solution of (5-methylpyrazin-2-yl)methanol (500 mg, 4.028 mmol, commercial source: Combi- Blocks) in dichloromethane (20 mL), thionyl chloride (0.35 mL, 4.825 mmol, Commercial source: Avra) was added slowly at 0 °C. The reaction mixture was allowed to reach 26 °C and stirred for 16 h at the same temperature. Upon completion, the reaction mixture was concentrated under reduced pressure. The residue was neutralized with saturated sodium bicarbonate solution (20 mL) and extracted with ethyl acetate (3x20 mL). The combined organic solution was dried over Na2S04, filtered and the filtrate was concentrated under reduced pressure to afford 2- (chloromethyl)-5-methylpyrazine (500 mg, crude) as a brown liquid.1H NMR (400 MHz, CDCI3) δ 8.60 (s, 1 H), 8.43 (s, 1 H), 4.67 (s, 2H), 2.59 (s, 3H). MS m/z [M+H]+= 143.04
References:
GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED;ALEMPARTE-GALLARDO, Carlos;ENCINAS, Lourdes;ESQUIVIAS PROVENCIO, Jorge WO2019/34729, 2019, A1 Location in patent:Page/Page column 92
123-32-0
514 suppliers
$6.00/5g
81831-68-7
42 suppliers
$72.00/100 mg
123-32-0
514 suppliers
$6.00/5g
![Ethanamine, N-[(3,5-dichlorophenyl)methylene]-2,2-diethoxy-](/CAS/20210305/GIF/1000210-73-0.gif)
1000210-73-0
0 suppliers
inquiry
81831-68-7
42 suppliers
$72.00/100 mg
58549-95-4
6 suppliers
inquiry