2-(CHLOROMETHYL)-6-METHYL QUINOLINE synthesis
- Product Name:2-(CHLOROMETHYL)-6-METHYL QUINOLINE
- CAS Number:22989-38-4
- Molecular formula:C11H10ClN
- Molecular Weight:191.66
877-43-0
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Yield:22989-38-4 70%
Reaction Conditions:
with tetra-(n-butyl)ammonium iodide;1,2-dichloro-ethane;urea at 110; for 0.5 h;Microwave irradiation;Reagent/catalyst;
Steps:
General procedure for chlorination of 2-methylquinolines:
General procedure: 2-Methylquinolines 1(2 mmol), TBAI (2 mmol), urea (2 mmol), and 1,2-dichloroethane (10 mL) weremixed in a microwave tube. The reaction mixture was stirred at 110 °C for 30 min under microwave irradiation using a CEM Discover microwave reactor(the highest power: 150 W; run time: 5 min; hold time: 30 min; temperature:110 °C). The resulting reaction mixture was concentrated in vacuo, and the crude residue was purified by flash chromatography on silica gel using hexane/EtOAc as eluent.
References:
Xie, Yuanyuan;Li, Lehuan [Tetrahedron Letters,2014,vol. 55,# 29,p. 3892 - 3895] Location in patent:supporting information
20531-91-3
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22989-38-4
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