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709-79-5

2-CYANO-3-PHENYLACRYLAMIDE synthesis

9synthesis methods
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Yield:709-79-5 100%

Reaction Conditions:

Stage #1: 5-amino-3-phenyl-2,3-dihydroisoxazole-4-carbonitrilewith hydrogenchloride in water at 20; pH=1 - 3; for 0.5 h;
Stage #2: in water;chemoselective reaction;

References:

Li, Ping;Teng, Bo-Tao;Jin, Fa-Gen;Li, Xin-Sheng;Zhu, Wei-Dong;Xie, Jian-Wu [Organic and Biomolecular Chemistry,2012,vol. 10,# 2,p. 244 - 247] Location in patent:supporting information; experimental part