2-Cyano-5,6-dichloropyridine synthesis
- Product Name:2-Cyano-5,6-dichloropyridine
- CAS Number:185107-64-6
- Molecular formula:C6H2Cl2N2
- Molecular Weight:173
33252-29-8
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Yield:185107-64-6 98.4%
Reaction Conditions:
with phosphorus pentachloride;chlorine;tungsten(VI) chloride at 130 - 135; under 760.051 Torr; for 20 h;Catalytic behavior;Temperature;Reagent/catalyst;
Steps:
1-2; 4-11 Example 1
General procedure: In a 1L four-necked flask equipped with a mechanical stirring and condensation device,Put in homemade 2-chloro 6-cyanopyridine (calculated as pure product,The same below) 600g, tungsten hexachloride 12g, phosphorus pentachloride 12g, atmospheric pressure,Heat up to 150 , start stirring, and continuously introduce chlorine gas at a rate of 100mL/min.Control the reaction temperature at 150 ~ 155 , continuous reaction for 20h,Sampling gas chromatography analysis, raw material conversion rate and product yield are shown in Table 2.
References:
CN111072558,2020,A Location in patent:Paragraph 0021-0024; 0027-0042; 0059-0065
100-70-9
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