2-(cyclopropylmethoxy)acetic acid synthesis
- Product Name:2-(cyclopropylmethoxy)acetic acid
- CAS Number:246869-08-9
- Molecular formula:C6H10O3
- Molecular Weight:130.14
2516-33-8
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$9.00/1g
79-08-3
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246869-08-9
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$95.00/50mg
Yield: 90%
Reaction Conditions:
with potassium tert-butylate in tetrahydrofuran at -5 - 5; for 18 h;Temperature;Solvent;
Steps:
2d Example-2d: Preparation of (cyclopropylmethoxy)acetic acid
Potassium ie/t-butoxide (312 g; 2.78 mol) and THF (800 mL) were added into a flask, cooled to -5 to 5 °C. Cyclopropylcarbinol (100 g; 1.39 mol) was slowly added, bromoacetic acid (144 g; 1.53 mol) in THF was added slowly and stirring continued for 18 hours. Water (1000 mL) and MDC (500 mL) were added. Then con.HCl was added. The organic layer was separated and MDC was distilled out to obtain the title compound. Yield: 162.5 g; 90%.
References:
SEQUENT SCIENTIFIC LIMITED;RAMASAMY, Suresh;SINGANAN, Ponnuchamy;BARVE, Hariprasad;BETTADAPURA GUNDAPPA, Krishna;HOLKAR, Anil Ganpatrao WO2018/109781, 2018, A1 Location in patent:Page/Page column 22
2516-33-8
295 suppliers
$9.00/1g
3926-62-3
297 suppliers
$16.69/250g
246869-08-9
32 suppliers
$95.00/50mg